IUBMB Enzyme Nomenclature


Accepted name: (S)-tetrahydroprotoberberine N-methyltransferase

Reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine

For diagram click here or here or click here.

Other name(s): tetrahydroprotoberberine cis-N-methyltransferase

Systematic name: S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase

Comments: involved in the biosynthesis of isoquinoline alkaloids in plants.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 106878-42-6


1. Rueffer, M., Zumstein, G., Zenk, M.H. Partial purification and characterization of S-adenosyl-L-methionine:(S)-tetrahydroprotoberberine cis-N-methyltransferase from suspension-cultured cells of Eschscholtzia and Corydalis. Phytochemistry 29 (1990) 3727-3733.

[EC created 1999]

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