IUBMB Enzyme Nomenclature


Accepted name: (RS)-norcoclaurine 6-O-methyltransferase

Reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine

For diagram click here.

Norcoclaurine: 6,7-dihydroxy-1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline

Systematic name: S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase

Comments: the enzyme will also catalyse the 6-O-methylation of (RS)-norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 89700-33-4


1. Rueffer, M., Nagakura, N., Zenk, M.H. Partial purification and properties of S-adenosyl-L-methionine:(R),(S)-norlaudanosoline-6-O-methyltransferase from Argemone platyceras cell cultures. Planta Med. 49 (1983) 131-137.

2. Sato, F., Tsujita, T., Katagiri, Y., Yoshida, S., Yamada, Y. Purification and characterization of S-adenosyl-L-methionine:norcoclaurine-6-O-methyltransferase from cultured Coptis japonica cells. Eur. J. Biochem. 225 (1994) 125-131. [PMID: 7925429]

3. Stadler, R., Zenk, M.H. A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline. Liebigs Ann. Chem. (1990) 555-562.

[EC created 1999]

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