IUBMB Enzyme Nomenclature


Accepted name: inositol 4-methyltransferase

Reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-4-O-methyl-myo-inositol

For diagram click here.

Other name(s): myo-inositol 4-O-methyltransferase; S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase; myo-inositol 6-O-methyltransferase

Systematic name: S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase

Comments: The enzyme from the rice bean Vigna umbellata (Fabaceae) is highly specific for S-adenosyl-L-methionine. The enzyme also methylates 1L-1,2,4/3,5-cyclohexanepentol, 2,4,6/3,5-pentahydroxycyclohexanone, D,L-2,3,4,6/5-pentacyclohexanone and 2,2'-anhydro-2-C-hydroxymethyl-myo-inositol, but at lower rates than that of myo-inositol.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 169277-48-9


1. Vernon, D.M., Bohnert, H.J. A novel methyl transferase induced by osmotic stress in the facultative halophyte Mesembryanthemum crystallinum. EMBO J. 11 (1992) 2077-2085. [PMID: 1600940]

2. Wanek, W. and Richter, A. Purification and characterization of myo-inositol 6-O-methyltransferase from Vigna umbellata Ohwi et Ohashi. Planta 197 (1995) 427-434.

[EC created 1999 (EC created 1999, incorporated 2002), modified 2002]

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