IUBMB Enzyme Nomenclature


Accepted name: isoliquiritigenin 2'-O-methyltransferase

Reaction: S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin

For diagram click here.

Glossary: isoliquiritigenin = 4,2',4'-trihydroxychalcone

Other name(s): chalcone OMT; CHMT

Systematic name: S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase

Comments: Not identical to EC, licodione 2'-O-methyltransferase [2]. While EC, isoliquiritigenin 2'-O-methyltransferase can use licodione as a substrate, EC cannot use isoliquiritigenin as a substrate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 139317-14-9


1. Maxwell, C.A., Edwards, R. and Dixon R.A. Identification, purification, and characterization of S-adenosyl-L-methionine: isoliquiritigenin 2'-O-methyltransferase from alfalfa (Medicago sativa L.). Arch. Biochem. Biophys. 293 (1992) 158-166. [PMID: 1731632]

2. Ichimura, M., Furuno, T., Takahashi, T., Dixon, R.A. and Ayabe, S. Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures. Phytochemistry 44 (1997) 991-995. [PMID: 9055445]

[EC created 2004]

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