IUBMB Enzyme Nomenclature


Accepted name: 16S rRNA (guanine966-N2)-methyltransferase

Reaction: S-adenosyl-L-methionine + guanine966 in 16S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine966 in 16S rRNA

Other name(s): yhhF (gene name); rsmD (gene name); m2G966 methyltransferase

Systematic name: S-adenosyl-L-methionine:16S rRNA (guanine966-N2)-methyltransferase

Comments: The enzyme efficiently methylates guanine966 of the assembled 30S subunits in vitro. Protein-free 16S rRNA is not a substrate for RsmD [1]. The enzyme specifically methylates guanine966 at N2 in 16S rRNA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Lesnyak, D.V., Osipiuk, J., Skarina, T., Sergiev, P.V., Bogdanov, A.A., Edwards, A., Savchenko, A., Joachimiak, A. and Dontsova, O.A. Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure. J. Biol. Chem. 282 (2007) 5880-5887. [PMID: 17189261]

[EC created 1976 as EC, part transferred 2010 to EC]

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