IUBMB Enzyme Nomenclature


Accepted name: 23S rRNA (guanine1835-N2)-methyltransferase

Reaction: S-adenosyl-L-methionine + guanine1835 in 23S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine1835 in 23S rRNA

Other name(s): ygjO (gene name); rlmG (gene name); ribosomal RNA large subunit methyltransferase G

Systematic name: S-adenosyl-L-methionine:23S rRNA (guanine1835-N2)-methyltransferase

Comments: The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate [1]. The enzyme specifically methylates guanine1835 at N2 in 23S rRNA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Sergiev, P.V., Lesnyak, D.V., Bogdanov, A.A. and Dontsova, O.A. Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA. J. Mol. Biol. 364 (2006) 26-31. [PMID: 17010380]

[EC created 1976 as EC, part transferred 2010 to EC]

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