IUBMB Enzyme Nomenclature


Accepted name: 16S rRNA (cytosine967-C5)-methyltransferase

Reaction: S-adenosyl-L-methionine + cytosine967 in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine967 in 16S rRNA

Other name(s): rsmB (gene name); fmu (gene name); 16S rRNA m5C967 methyltransferase

Systematic name: S-adenosyl-L-methionine:16S rRNA (cytosine967-C5)-methyltransferase

Comments: The enzyme specifically methylates cytosine967 at C5 in 16S rRNA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Tscherne, J.S., Nurse, K., Popienick, P., Michel, H., Sochacki, M. and Ofengand, J. Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli. Biochemistry 38 (1999) 1884-1892. [PMID: 10026269]

2. Gu, X.R., Gustafsson, C., Ku, J., Yu, M. and Santi, D.V. Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli. Biochemistry 38 (1999) 4053-4057. [PMID: 10194318]

3. Foster, P.G., Nunes, C.R., Greene, P., Moustakas, D. and Stroud, R.M. The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate. Structure 11 (2003) 1609-1620. [PMID: 14656444]

[EC created 2010]

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