IUBMB Enzyme Nomenclature


Accepted name: 23S rRNA (guanosine2251-2'-O)-methyltransferase

Reaction: S-adenosyl-L-methionine + guanosine2251 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA

Other name(s): rlmB (gene name); yifH (gene name)

Systematic name: S-adenosyl-L-methionine:23S rRNA (guanosine2251-2'-O)-methyltransferase

Comments: The enzyme catalyses the methylation of guanosine2251, a modification conserved in the peptidyltransferase domain of 23S rRNA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Lovgren, J.M. and Wikstrom, P.M. The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli. J. Bacteriol. 183 (2001) 6957-6960. [PMID: 11698387]

2. Michel, G., Sauve, V., Larocque, R., Li, Y., Matte, A. and Cygler, M. The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot. Structure 10 (2002) 1303-1315. [PMID: 12377117]

[EC created 2010]

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