IUBMB Enzyme Nomenclature


Accepted name: 23S rRNA (cytosine1962-C5)-methyltransferase

Reaction: S-adenosyl-L-methionine + cytosine1962 in 23S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine1962 in 23S rRNA

Other name(s): RlmI; rRNA large subunit methyltransferase I; YccW

Systematic name: S-adenosyl-L-methionine:23S rRNA (cytosine1962-C5)-methyltransferase

Comments: The enzyme specifically methylates cytosine1962 at C5 in 23S rRNA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Purta, E., O'Connor, M., Bujnicki, J.M. and Douthwaite, S. YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962. J. Mol. Biol. 383 (2008) 641-651. [PMID: 18786544]

2. Sunita, S., Tkaczuk, K.L., Purta, E., Kasprzak, J.M., Douthwaite, S., Bujnicki, J.M. and Sivaraman, J. Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes. J. Mol. Biol. 383 (2008) 652-666. [PMID: 18789337]

[EC created 2010]

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