IUBMB Enzyme Nomenclature


Accepted name: tRNA (cytidine32/guanosine34-2'-O)-methyltransferase

Reaction: S-adenosyl-L-methionine + cytidine32/guanosine34 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA

Other name(s): Trm7p

Systematic name: S-adenosyl-L-methionine:tRNA (cytidine32/guanosine34-2'-O)-methyltransferase

Comments: The enzyme from Saccharomyces cerevisiae catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe, tRNATrp and, possibly, tRNALeu.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Pintard, L., Lecointe, F., Bujnicki, J.M., Bonnerot, C., Grosjean, H. and Lapeyre, B. Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. EMBO J. 21 (2002) 1811-1820. [PMID: 11927565]

[EC created 2011]

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