IUBMB Enzyme Nomenclature


Accepted name: tRNA (cytidine56-2'-O)-methyltransferase

Reaction: S-adenosyl-L-methionine + cytidine56 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA

Other name(s): aTrm56; tRNA ribose 2'-O-methyltransferase aTrm56; PAB1040 (gene name)

Systematic name: S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase

Comments: The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Renalier, M.H., Joseph, N., Gaspin, C., Thebault, P. and Mougin, A. The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP. RNA 11 (2005) 1051-1063. [PMID: 15987815]

2. Kuratani, M., Bessho, Y., Nishimoto, M., Grosjean, H. and Yokoyama, S. Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA. J. Mol. Biol. 375 (2008) 1064-1075. [PMID: 18068186]

[EC created 2011]

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