IUBMB Enzyme Nomenclature


Accepted name: tRNA (adenine22-N1)-methyltransferase

Reaction: S-adenosyl-L-methionine + adenine22 in tRNA = S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA

Other name(s): TrmK; YqfN; Sp1610 (gene name); tRNA: m1A22 methyltransferase

Systematic name: S-adenosyl-L-methionine:tRNA (adenine22-N1)-methyltransferase

Comments: The enzyme specifically methylates adenine22 in tRNA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Ta, H.M. and Kim, K.K. Crystal structure of Streptococcus pneumoniae Sp1610, a putative tRNA methyltransferase, in complex with S-adenosyl-L-methionine. Protein Sci. 19 (2010) 617-624. [PMID: 20052680]

2. Roovers, M., Kaminska, K.H., Tkaczuk, K.L., Gigot, D., Droogmans, L. and Bujnicki, J.M. The YqfN protein of Bacillus subtilis is the tRNA: m1A22 methyltransferase (TrmK). Nucleic Acids Res. 36 (2008) 3252-3262. [PMID: 18420655]

[EC created 2011 (EC created 1972, part transferred 2011 to EC]

Return to EC 2.1.1 home page
Return to EC 2.1 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page