IUBMB Enzyme Nomenclature


Accepted name: tRNA:m4X modification enzyme

Reaction: (1) S-adenosyl-L-methionine + cytidine4 in tRNAPro = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAPro
(2) S-adenosyl-L-methionine + cytidine4 in tRNAGly(GCC) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAGly(GCC)
(3) S-adenosyl-L-methionine + adenosine4 in tRNAHis = S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNAHis

Other name(s): TRM13; Trm13p; tRNA:Xm4 modification enzyme

Systematic name: S-adenosyl-L-methionine:tRNAPro/His/Gly(GCC) (cytidine/adenosine4-2'-O)-methyltransferase

Comments: The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine4 in tRNAPro and tRNAGly(GCC), and adenosine4 in tRNAHis.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Wilkinson, M.L., Crary, S.M., Jackman, J.E., Grayhack, E.J. and Phizicky, E.M. The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4. RNA 13 (2007) 404-413. [PMID: 17242307]

[EC created 2011]

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