IUBMB Enzyme Nomenclature


Accepted name: flavonoid 4'-O-methyltransferase

Reaction: S-adenosyl-L-methionine + a 4'-hydroxyflavanone = S-adenosyl-L-homocysteine + a 4'-methoxyflavanone

For diagram of reaction, click here

Other name(s): SOMT-2; 4'-hydroxyisoflavone methyltransferase

Systematic name: S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase

Comments: The enzyme catalyses the 4'-methylation of naringenin. In vitro it catalyses the 4'-methylation of apigenin, quercetin, daidzein and genistein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kim, D.H., Kim, B.G., Lee, Y., Ryu, J.Y., Lim, Y., Hur, H.G. and Ahn, J.H. Regiospecific methylation of naringenin to ponciretin by soybean O-methyltransferase expressed in Escherichia coli. J. Biotechnol. 119 (2005) 155-162. [PMID: 15961179]

[EC created 2011]

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