IUBMB Enzyme Nomenclature


Accepted name: trans-resveratrol di-O-methyltransferase

Reaction: 2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction)
(1a) S-adenosyl-L-methionine + trans-resveratrol = S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene
(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene = S-adenosyl-L-homocysteine + pterostilbene

For diagram of reaction click here.

Glossary: 3-methoxy-4',5-dihydroxy-trans-stilbene = resveratrol monomethyl ether
pterostilbene = 3,5-dimethoxy-4'-hydroxy-trans-stilbene
trans-resveratrol = 3,4',5-trihydroxy-trans-stilbene

Other name(s): ROMT; resveratrol O-methyltransferase; pterostilbene synthase

Systematic name: S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase

Comments: The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Schmidlin, L., Poutaraud, A., Claudel, P., Mestre, P., Prado, E., Santos-Rosa, M., Wiedemann-Merdinoglu, S., Karst, F., Merdinoglu, D. and Hugueney, P. A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine. Plant Physiol. 148 (2008) 1630-1639. [PMID: 18799660]

[EC created 2012]

Return to EC 2.1.1 home page
Return to EC 2.1 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page