IUBMB Enzyme Nomenclature


Accepted name: dimethylamine—corrinoid protein Co-methyltransferase

Reaction: dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein] = a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine

Other name(s): mtbB (gene name); dimethylamine methyltransferase

Systematic name: dimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase

Comments: The enzyme, which catalyses the transfer of a methyl group from dimethylamine to a dimethylamine-specific corrinoid protein (MtbC), is involved in methanogenesis from dimethylamine. The enzyme contains the unusual amino acid pyrrolysine [3]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Wassenaar, R.W., Keltjens, J.T., van der Drift, C. and Vogels, G.D. Purification and characterization of dimethylamine:5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro. Eur. J. Biochem. 253 (1998) 692-697. [PMID: 9654067]

2. Ferguson, D.J., Jr., Gorlatova, N., Grahame, D.A. and Krzycki, J.A. Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri. J. Biol. Chem. 275 (2000) 29053-29060. [PMID: 10852929]

3. Krzycki, J.A. Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases. Curr. Opin. Chem. Biol. 8 (2004) 484-491. [PMID: 15450490]

[EC created 2012]

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