IUBMB Enzyme Nomenclature


Accepted name: [methyl-Co(III) tetramethylammonium-specific corrinoid protein]—coenzyme M methyltransferase

Reaction: a [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) tetramethylammonium-specific corrinoid protein]

Glossary: CoM = coenzyme M = 2-sulfanylethane-1-sulfonate = 2-mercaptoethanesulfonate (deprecated)

Other name(s): methyltransferase 2 (ambiguous); mtqA (gene name)

Systematic name: methylated tetramethylammonium-specific corrinoid protein:Coenzyme M methyltransferase

Comments: The enzyme, which is involved in methanogenesis from tetramethylammonium, catalyses the transfer of a methyl group from a corrinoid protein (see EC, tetramethylammonium—corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to coenzyme M, forming the substrate for EC, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Asakawa, S., Sauer, K., Liesack, W. and Thauer, R.K. Tetramethylammonium:coenzyme M methyltransferase system from methanococcoides s. Arch. Microbiol. 170 (1998) 220-226. [PMID: 9732435]

[EC created 2012]

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