IUBMB Enzyme Nomenclature


Accepted name: tRNA (guanine6-N2)-methyltransferase

Reaction: S-adenosyl-L-methionine + guanine6 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA

Other name(s): methyltransferase Trm14; m2G6 methyltransferase

Systematic name: S-adenosyl-L-methionine:tRNA (guanine6-N2)-methyltransferase

Comments: The enzyme specifically methylates guanine6 at N2 in tRNA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Menezes, S., Gaston, K.W., Krivos, K.L., Apolinario, E.E., Reich, N.O., Sowers, K.R., Limbach, P.A. and Perona, J.J. Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14. Nucleic Acids Res. 39 (2011) 7641-7655. [PMID: 21693558]

[EC created 2012]

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