IUBMB Enzyme Nomenclature


Accepted name: 4-dimethylallyltryptophan N-methyltransferase

Reaction: S-adenosyl-L-methionine + 4-prenyl-L-tryptophan = S-adenosyl-L-homocysteine + 4-prenyl-L-abrine

For diagram of reaction click here.

Glossary: 4-prenyl-L-tryptophan = 4-(3-methylbut-2-enyl)-L-tryptophan = 4-dimethylallyl-L-tryptophan (ambiguous);
4-prenyl-L-abrine = 4-(3-methylbut-2-enyl)-L-abrine = 4-dimethylallyl-L-abrine (ambiguous)

Other name(s): fgaMT (gene name); easF (gene name)

Systematic name: S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase

Comments: The enzyme catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in certain fungi.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Rigbers, O. and Li, S.M. Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase. J. Biol. Chem. 283 (2008) 26859-26868. [PMID: 18678866]

[EC created 2012]

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