IUBMB Enzyme Nomenclature


Accepted name: 23S rRNA (guanine2069-N7)-methyltransferase

Reaction: S-adenosyl-L-methionine + guanine2069 in 23S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine2069 in 23S rRNA

Other name(s): rlmK (gene name); 23S rRNA m7G2069 methyltransferase

Systematic name: S-adenosyl-L-methionine:23S rRNA (guanine2069-N7)-methyltransferase

Comments: The enzyme specifically methylates guanine2069 at position N7 in 23S rRNA. In γ-proteobacteria the enzyme also catalyses EC, 23S rRNA (guanine2445-N2)-methyltransferase, while in β-proteobacteria the activities are carried out by separate proteins [1]. The enzyme from the γ-proteobacterium Escherichia coli has RNA unwinding activity as well [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Kimura, S., Ikeuchi, Y., Kitahara, K., Sakaguchi, Y., Suzuki, T. and Suzuki, T. Base methylations in the double-stranded RNA by a fused methyltransferase bearing unwinding activity. Nucleic Acids Res. 40 (2012) 4071-4085. [PMID: 22210896]

[EC created 2012]

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