IUBMB Enzyme Nomenclature


Accepted name: 23S rRNA (adenine2030-N6)-methyltransferase

Reaction: S-adenosyl-L-methionine + adenine2030 in 23S rRNA = S-adenosyl-L-homocysteine + N6-methyladenine2030 in 23S rRNA

Other name(s): YhiR protein; rlmJ (gene name); m6A2030 methyltransferase

Systematic name: S-adenosyl-L-methionine:23S rRNA (adenine2030-N6)-methyltransferase

Comments: The recombinant RlmJ protein is most active in methylating deproteinized 23S ribosomal subunit, and does not methylate the completely assembled 50S subunits [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Golovina, A.Y., Dzama, M.M., Osterman, I.A., Sergiev, P.V., Serebryakova, M.V., Bogdanov, A.A. and Dontsova, O.A. The last rRNA methyltransferase of E. coli revealed: the yhiR gene encodes adenine-N6 methyltransferase specific for modification of A2030 of 23S ribosomal RNA. RNA 18 (2012) 1725-1734. [PMID: 22847818]

[EC created 2013]

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