IUBMB Enzyme Nomenclature


Accepted name: 8-demethylnovobiocic acid C8-methyltransferase

Reaction: S-adenosyl-L-methionine + 8-demethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid

For diagram of reaction click here.

Glossary: novobiocic acid = N-(2,7-dihydroxy-8-methyl-4-oxochromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl) benzamide

Other name(s): NovO

Systematic name: S-adenosyl-L-methionine:8-demethylnovobiocic acid C8-methyltransferase

Comments: The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin.

Links to other databases: BRENDA, EXPASY, KEGG Metacyc, PDB, CAS registry number:


1. Pacholec, M., Tao, J. and Walsh, C.T. CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis. Biochemistry 44 (2005) 14969-14976. [PMID: 16274243]

[EC created 2013]

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