IUBMB Enzyme Nomenclature


Accepted name: 25S rRNA (adenine2142-N1)-methyltransferase

Reaction: S-adenosyl-L-methionine + adenine2142 in 25S rRNA = S-adenosyl-L-homocysteine + N1-methyladenine2142 in 25S rRNA

Other name(s): BMT2 (gene name); 25S rRNA m1A2142 methyltransferase

Systematic name: S-adenosyl-L-methionine:25S rRNA (adenine2142-N1)-methyltransferase

Comments: In the yeast Saccharomyces cerevisiae this methylation is important for resistance towards hydrogen peroxide and the antibiotic anisomycin.

Links to other databases: BRENDA, EXPASY, KEGG Metacyc, CAS registry number:


1. Sharma, S., Watzinger, P., Kotter, P. and Entian, K.D. Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae. Nucleic Acids Res. 41 (2013) 5428-5443. [PMID: 23558746]

[EC created 2013]

Return to EC 2.1.1 home page
Return to EC 2.1 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page