IUBMB Enzyme Nomenclature

EC 2.1.1.286

Accepted name: 25S rRNA (adenine2142-N1)-methyltransferase

Reaction: S-adenosyl-L-methionine + adenine2142 in 25S rRNA = S-adenosyl-L-homocysteine + N1-methyladenine2142 in 25S rRNA

Other name(s): BMT2 (gene name); 25S rRNA m1A2142 methyltransferase

Systematic name: S-adenosyl-L-methionine:25S rRNA (adenine2142-N1)-methyltransferase

Comments: In the yeast Saccharomyces cerevisiae this methylation is important for resistance towards hydrogen peroxide and the antibiotic anisomycin.

Links to other databases: BRENDA, EXPASY, KEGG Metacyc, CAS registry number:

References:

1. Sharma, S., Watzinger, P., Kotter, P. and Entian, K.D. Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae. Nucleic Acids Res. 41 (2013) 5428-5443. [PMID: 23558746]

[EC 2.1.1.286 created 2013]


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