IUBMB Enzyme Nomenclature


Accepted name: 25S rRNA (adenine645-N1)-methyltransferase

Reaction: S-adenosyl-L-methionine + adenine645 in 25S rRNA = S-adenosyl-L-homocysteine + N1-methyladenine645 in 25S rRNA

Other name(s): 25S rRNA m1A645 methyltransferase; Rrp8

Systematic name: S-adenosyl-L-methionine:25S rRNA (adenine645-N1)-methyltransferase

Comments: The enzyme is found in eukaryotes. The adenine position refers to tRNA the yeast Saccharomyces cerevisiae, in which the enzyme is important for ribosome biogenesis.

Links to other databases: BRENDA, EXPASY, KEGG Metacyc, CAS registry number:


1. Peifer, C., Sharma, S., Watzinger, P., Lamberth, S., Kotter, P. and Entian, K.D. Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA. Nucleic Acids Res. 41 (2013) 1151-1163. [PMID: 23180764]

[EC created 2013]

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