IUBMB Enzyme Nomenclature


Accepted name: ribosomal protein uL3 N5-glutamine methyltransferase

Reaction: S-adenosyl-L-methionine + [ribosomal protein uL3]-L-glutamine = S-adenosyl-L-homocysteine + [ribosomal protein uL3]-N5-methyl-L-glutamine

Other name(s): YfcB; PrmB

Systematic name: S-adenosyl-L-methionine:[ribosomal protein uL3]-L-glutamine (N5-glutamine)-methyltransferase

Comments: Modifies the glutamine residue in the glycylglycylglutamine (GGQ) motif of ribosomal protein uL3 (Gln150 in the protein from the bacterium Escherichia coli). The enzyme does not act on peptide chain release factor 1 or 2.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Heurgue-Hamard, V., Champ, S., Engstrom, A., Ehrenberg, M. and Buckingham, R.H. The hemK gene in Escherichia coli encodes the N5-glutamine methyltransferase that modifies peptide release factors. EMBO J. 21 (2002) 769-778. [PMID: 11847124]

[EC created 2014, modified 2023]

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