IUBMB Enzyme Nomenclature


Accepted name: thetin—homocysteine S-methyltransferase

Reaction: dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + L-methionine

Glossary: thetin = sulfobetaine = dimethylsulfonioacetate

Other name(s): dimethylthetin-homocysteine methyltransferase; thetin-homocysteine methylpherase

Systematic name: dimethylsulfonioacetate:L-homocysteine S-methyltransferase

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, CAS registry number: 9029-76-9


1. Klee, W.A., Richards, H.H. and Cantoni, G.L. The synthesis of methionine by enzymic transmethylation. VII. Existence of two separate homocysteine methylpherases on mammalian liver. Biochim. Biophys. Acta 54 (1961) 157-164.

2. Maw, G.A. Thetin-homocysteine transmethylase. A preliminary manometric study of the enzyme from rat liver. Biochem. J. 63 (1956) 116-124.

3. Maw, G.A. Thetin-homocysteine transmethylase. Some further characteristics of the enzyme from rat liver. Biochem. J. 70 (1958) 168-173.

[EC created 1961]

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