IUBMB Enzyme Nomenclature


Accepted name: L-tyrosine C3-methyltransferase

Reaction: S-adenosyl-L-methionine + L-tyrosine = S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine

For diagram of reaction click here.

Other name(s): SfmM2; SacF

Systematic name: S-adenosyl-L-methionine:L-tyrosine C3-methyltransferase

Comments: The enzyme from the bacterium Streptomyces lavendulae is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Tang, M.C., Fu, C.Y. and Tang, G.L. Characterization of SfmD as a heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis. J. Biol. Chem. 287 (2012) 5112-5121. [PMID: 22187429]

[EC created 2014]

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