IUBMB Enzyme Nomenclature


Accepted name: 18S rRNA (guanine1575-N7)-methyltransferase

Reaction: S-adenosyl-L-methionine + guanine1575 in 18S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine1575 in 18S rRNA

Other name(s): 18S rRNA methylase Bud23; BUD23 (gene name)

Systematic name: S-adenosyl-L-methionine:18S rRNA (guanine1575-N7)-methyltransferase

Comments: The enzyme, found in eukaryotes, is involved in pre-rRNA processing. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae [1].

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. White, J., Li, Z., Sardana, R., Bujnicki, J.M., Marcotte, E.M. and Johnson, A.W. Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits. Mol. Cell Biol. 28 (2008) 3151-3161. [PMID: 18332120]

[EC created 2014]

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