IUBMB Enzyme Nomenclature


Accepted name: 25S rRNA (cytosine2278-C5)-methyltransferase

Reaction: S-adenosyl-L-methionine + cytosine2278 in 25S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA

Other name(s): RCM1 (gene name)

Systematic name: S-adenosyl-L-methionine:25S rRNA (cytosine2278-C5)-methyltransferase

Comments: The enzyme, found in eukaryotes, is specific for 25S cytosine2278. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae [1].

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Sharma, S., Yang, J., Watzinger, P., Kotter, P. and Entian, K.D. Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively. Nucleic Acids Res. 41 (2013) 9062-9076. [PMID: 23913415]

[EC created 2014]

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