IUBMB Enzyme Nomenclature


Accepted name: 27-O-demethylrifamycin SV methyltransferase

Reaction: S-adenosyl-L-methionine + 27-O-demethylrifamycin SV = S-adenosyl-L-homocysteine + rifamycin SV

Glossary: rifamycin SV = (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[,7.05,28]triaconta-1(28),2,4,9, 19,21,25(29),26-octaen-13-yl acetate

Other name(s): AdoMet:27-O-demethylrifamycin SV methyltransferase

Systematic name: S-adenosyl-L-methionine:27-O-demethylrifamycin-SV 27-O-methyltransferase

Comments: The enzyme, characterized from the bacterium Amycolatopsis mediterranei, is involved in biosynthesis of the antitubercular drug rifamycin B.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Xu, J., Mahmud, T. and Floss, H.G. Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699. Arch. Biochem. Biophys. 411 (2003) 277-288. [PMID: 12623077]

[EC created 2015]

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