IUBMB Enzyme Nomenclature


Accepted name: phenazine-1-carboxylate N-methyltransferase

Reaction: S-adenosyl-L-methionine + phenazine-1-carboxylate = S-adenosyl-L-homocysteine + 5-methyl-phenazine-1-carboxylate

For diagram of reaction click here.

Other name(s): phzM (gene name)

Systematic name: S-adenosyl-L-methionine:phenazine-1-carboxylate 5-N-methyltransferase

Comments: The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in the biosynthesis of pyocyanin, a toxin produced and secreted by the organism. The enzyme is active in vitro only in the presence of EC, 5-methylphenazine-1-carboxylate 1-monooxygenase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Parsons, J.F., Greenhagen, B.T., Shi, K., Calabrese, K., Robinson, H. and Ladner, J.E. Structural and functional analysis of the pyocyanin biosynthetic protein PhzM from Pseudomonas aeruginosa. Biochemistry 46 (2007) 1821-1828. [PMID: 17253782]

[EC created 2016]

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