IUBMB Enzyme Nomenclature


Accepted name: N-demethylindolmycin N-methyltransferase

Reaction: S-adenosyl-L-methionine + N-demethylindolmycin = S-adenosyl-L-homocysteine + indolmycin

Glossary: indolmycin = (5S)-5-[(1R)-1-(indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazolin-4(5H)-one

Other name(s): ind7 (gene name)

Systematic name: S-adenosyl-L-methionine:N-demethylindolmycin N-methyltransferase

Comments: The enzyme, characterized from the bacterium Streptomyces griseus, catalyses the ultimate reaction in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan—tRNA ligase (EC

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Du, Y.L., Alkhalaf, L.M. and Ryan, K.S. In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly. Proc. Natl. Acad. Sci. USA 112 (2015) 2717-2722. [PMID: 25730866]

[EC created 2016]

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