IUBMB Enzyme Nomenclature


Accepted name: desmethylxanthohumol 6'-O-methyltransferase

Reaction: S-adenosyl-L-methionine + desmethylxanthohumol = S-adenosyl-L-homocysteine + xanthohumol

For diagram of reaction click here.

Glossary: desmethylxanthohumol = 2′,4,4′,6′-tetrahydroxy-3-prenylchalcone = (2E)-3-(4-hydroxyphenyl)-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]prop-2-en-1-one
xanthohumol = (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one

Other name(s): OMT1 (ambiguous)

Systematic name: S-adenosyl-L-methionine:desmethylxanthohumol 6'-O-methyltransferase

Comments: Found in hops (Humulus lupulus). The enzyme can also methylate xanthogalenol.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Nagel, J., Culley, L.K., Lu, Y., Liu, E., Matthews, P.D., Stevens, J.F. and Page, J.E. EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol. Plant Cell 20 (2008) 186-200. [PMID: 18223037]

[EC created 2017]

Return to EC 2.1.1 home page
Return to EC 2.1 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page