IUBMB Enzyme Nomenclature


Accepted name: xanthohumol 4-O-methyltransferase

Reaction: S-adenosyl-L-methionine + xanthohumol = S-adenosyl-L-homocysteine + 4-O-methylxanthohumol
For diagram of reaction click here

Glossary: xanthohumol = 2',4,4'-trihydroxy-6'-methoxy-3-prenylchalcone = (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
4-O-methylxanthohumol =2',4'-dihydroxy-4,6'-dimethoxy-3-prenylchalcone = (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-methoxyphenyl)prop-2-en-1-one

Other name(s): OMT2 (ambiguous); S-adenosyl-L-methionine:xanthohumol 4'-O-methyltransferase (incorrect); xanthohumol 4'-O-methyltransferase (incorrect)

Systematic name: S-adenosyl-L-methionine:xanthohumol 4-O-methyltransferase

Comments: The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, naringenin chalcone and isoliquiritigenin.

Links to other databases: BRENDA, EXPASY, ExplorEnz, KEGG, MetaCyc, CAS registry number:


1. Nagel, J., Culley, L.K., Lu, Y., Liu, E., Matthews, P.D., Stevens, J.F. and Page, J.E. EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol. Plant Cell 20 (2008) 186-200. [PMID: 18223037]

[EC created 2017, modified 2018]

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