IUBMB Enzyme Nomenclature


Accepted name: mRNA m6A methyltransferase

Reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N6-methyladenine in mRNA

Other name(s): METTL3 (gene name); METTL14 (gene name)

Systematic name: S-adenosyl-L-methionine:adenine in mRNA methyltransferase

Comments: This enzyme, found in eukaryotes, methylates adenines in mRNA with the consensus sequence RRACH.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., Dai, Q., Chen, W. and He, C. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat. Chem. Biol. 10 (2014) 93-95. [PMID: 24316715]

2. Wang, X., Huang, J., Zou, T. and Yin, P. Human m6A writers: Two subunits, 2 roles. RNA Biol. 14 (2017) 300-304. [PMID: 28121234]

[EC created 2018]

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