IUBMB Enzyme Nomenclature


Accepted name: [histone H3]-lysine9 N-methyltransferase

Reaction: S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9

Other name(s): PRDM3 (gene name); PRDM16 (gene name)

Systematic name: S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-methyltransferase

Comments: This entry describes several enzymes that methylate the L-lysine-9 residue of histone H3 (H3K9) only once, generating a monomethylated form. These modifications influence the binding of chromatin-associated proteins. cf. EC, [histone H3]-lysine9 N-dimethyltransferase, EC, [histone H3]-lysine9 N-trimethyltransferase, and EC, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc PDB, CAS registry number:


1. Pinheiro, I., Margueron, R., Shukeir, N., Eisold, M., Fritzsch, C., Richter, F.M., Mittler, G., Genoud, C., Goyama, S., Kurokawa, M., Son, J., Reinberg, D., Lachner, M. and Jenuwein, T. Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell 150 (2012) 948-960. [PMID: 22939622]

[EC created 2020]

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