IUBMB Enzyme Nomenclature


Accepted name: [methyl-Co(III) glycine betaine-specific corrinoid protein]—coenzyme M methyltransferase

Reaction: a [methyl-Co(III) glycine betaine-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) glycine betaine-specific corrinoid protein]

Other name(s): mtaA (gene name)

Systematic name: methylated glycine betaine-specific corrinoid protein:CoM methyltransferase

Comments: The enzyme, which is involved in methanogenesis from glycine betaine, catalyses the transfer of a methyl group bound to the cobalt cofactor of glycine betaine-specific corrinoid protein to coenzyme M, forming the substrate for EC, coenzyme-B sulfoethylthiotransferase, which catalyses the final step in methanogenesis. The enzyme from the methanogenic archaeon Methanolobus vulcani B1d can also catalyse the activity of EC, [methyl-Co(III) methanol-specific corrinoid protein]—coenzyme M methyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Creighbaum, A.J., Ticak, T., Shinde, S., Wang, X. and Ferguson, D.J., Jr. Examination of the glycine betaine-dependent methylotrophic methanogenesis pathway: insights into anaerobic quaternary amine methylotrophy. Front. Microbiol. 10 (2019) 2572. [PMID: 31787957]

[EC created 2021]

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