IUBMB Enzyme Nomenclature


Accepted name: O-demethylpuromycin O-methyltransferase

Reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin

Other name(s): O-demethylpuromycin methyltransferase

Systematic name: S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase

Comments: Puromycin is the antibiotic derived from N6-dimethyladenosine by replacing the 3'-hydroxy group with an amino group and acylating this with 4-O-methyltyrosine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37257-04-8


1. Rao, M.M., Rebello, P.F. and Pogell, B.M. Biosynthesis of puromycin in Streptomyces alboniger. Enzymatic methylation of O-demethylpuromycin. J. Biol. Chem. 244 (1969) 112-118. [PMID: 5773275]

[EC created 1972]

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