IUBMB Enzyme Nomenclature


Accepted name: 3-amino-4-hydroxybenzoate 4-O-methyltransferase

Reaction: S-adenosyl-L-methionine + 3-amino-2,4-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-amino-2-hydroxy-4-methoxybenzoate

For diagram of reaction, click here

Glossary: cremeomycin = 6-carboxy-2-diazonio-3-methoxyphenolate

Other name(s): creN (gene name)

Systematic name: S-adenosyl-L-methionine:3-amino-4-hydroxybenzoate 4-O-methyltransferase

Comments: The enzyme, characterized from the bacterium Streptomyces cremeus, is involved in cremeomycin biosynthesis.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Waldman, A.J., Pechersky, Y., Wang, P., Wang, J.X. and Balskus, E.P. The cremeomycin biosynthetic gene cluster encodes a pathway for diazo formation. Chembiochem 16 (2015) 2172-2175. [PMID: 26278892]

[EC created 2021]

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