IUBMB Enzyme Nomenclature


Accepted name: arginine Nω-methyltransferase

Reaction: S-adenosyl-L-methionine + L-arginine = S-adenosyl-L-homocysteine + Nω-methyl-L-arginine

Other name(s): sznE (gene name); stzE (gene name)

Systematic name: S-adenosyl-L-methionine:L-arginine Nω-methyltransferase

Comments: The enzyme, characterized from the bacterium Streptomyces achromogenes subsp. streptozoticus, participates in the biosynthesis of the glucosamine-nitrosourea antibiotic streptozotocin.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Ng, T.L., Rohac, R., Mitchell, A.J., Boal, A.K. and Balskus, E.P. An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin. Nature 566 (2019) 94-99. [PMID: 30728519]

2. He, H.Y., Henderson, A.C., Du, Y.L. and Ryan, K.S. Two-enzyme pathway links l-arginine to nitric oxide in N-nitroso biosynthesis. J. Am. Chem. Soc. 141 (2019) 4026-4033. [PMID: 30763082]

[EC created 2021]

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