Reaction: S-adenosyl-L-methionine + demethylgadusol = S-adenosyl-L-homocysteine + gadusol
Glossary: demethylgadusol = (4R,5R)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohex-2-en-1-one
gadusol = (4R,5R)-3,4,5-trihydroxy-5-(hydroxymethyl)-2-methoxycyclohex-2-en-1-one
Other name(s): gadusol synthase; desmethyl gadusol O-methyltransferase
Systematic name: S-adenosyl-L-methionine:demethylgadusol 2-O-methyltransferase
Comments: The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 1.3.1.126, 2-epi-5-epi-valiolone dehydrogenase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Osborn, A.R., Almabruk, K.H., Holzwarth, G., Asamizu, S., LaDu, J., Kean, K.M., Karplus, P.A., Tanguay, R.L., Bakalinsky, A.T. and Mahmud, T. De novo synthesis of a sunscreen compound in vertebrates. Elife 4 (2015) . [PMID: 25965179]