IUBMB Enzyme Nomenclature


Accepted name: mRNA (2'-O-methyladenosine-N6-)-methyltransferase

Reaction: S-adenosyl-L-methionine + a 5-(N7-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N7-methyl 5-triphosphoguanosine)-N6,2'-O-dimethyladenosine-[mRNA]

Glossary: a 5-(N7-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA] = m7G(5')pppAm-[mRNA]
a 5-(N7-methyl 5-triphosphoguanosine)-N6,2'-O-dimethyladenosine-[mRNA] = m7G(5')pppm6Am-[mRNA]

Other name(s): messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase

Systematic name: S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 68009-87-0


1. Keith, J.M., Ensinger, M.J. and Moss, B. HeLa cell RNA (2'-O-methyladenosine-N6-)-methyltransferase specific for the capped 5'-end of messenger RNA. J. Biol. Chem. 253 (1978) 5033-5039. [PMID: 670176]

2. Mauer, J., Luo, X., Blanjoie, A., Jiao, X., Grozhik, A.V., Patil, D.P., Linder, B., Pickering, B.F., Vasseur, J.J., Chen, Q., Gross, S.S., Elemento, O., Debart, F., Kiledjian, M. and Jaffrey, S.R. Reversible methylation of m6Am in the 5' cap controls mRNA stability. Nature 541 (2017) 371-375. [PMID: 28002401]

[EC created 1982]

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