IUBMB Enzyme Nomenclature


Accepted name: apigenin 4'-O-methyltransferase

Reaction: S-adenosyl-L-methionine + apigenin = S-adenosyl-L-homocysteine + acacetin

For diagram click here.

Glossary: apigenin = 4′,5,7-trihydroxyflavone
acacetin = 4′-methoxy-5,7-dihydroxyflavone
naringenin = 4′,5,7-trihydroxyflavan-4-one

Other name(s): flavonoid O-methyltransferase; flavonoid methyltransferase

Systematic name: S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase

Comments: Converts apigenin into acacetin. Naringenin can also act as an acceptor, but more slowly.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 118251-36-8


1. Kuroki, G. and Poulton, J.E. The para-O-methylation of apigenin to acacetin by cell-free extracts of Robinia pseudoacacia L. Z. Naturforsch. C: Biosci. 36 (1981) 916-920.

[EC created 1984]

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