IUBMB Enzyme Nomenclature


Accepted name: protein-glutamate O-methyltransferase

Reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester

Other name(s): methyl-accepting chemotaxis protein O-methyltransferase; S-adenosylmethionine-glutamyl methyltransferase; methyl-accepting chemotaxis protein methyltransferase II; S-adenosylmethionine:protein-carboxyl O-methyltransferase; protein methylase II; MCP methyltransferase I; MCP methyltransferase II; protein O-methyltransferase; protein(aspartate)methyltransferase; protein(carboxyl)methyltransferase; protein carboxyl-methylase; protein carboxyl-O-methyltransferase; protein carboxylmethyltransferase II; protein carboxymethylase; protein carboxymethyltransferase; protein methyltransferase II

Systematic name: S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase

Comments: Forms ester groups with L-glutamate residues in a number of membrane proteins.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9055-09-8


1. Burgess-Cassler, A., Ulla, A.H.J. and Ordal, G.W. Purification and characterization of Bacillus subtilis methyl-accepting chemotaxis protein methyltransferase II. J. Biol. Chem. 257 (1982) 8412-8417. [PMID: 6806296]

2. Kleene, S.J., Toews, M.L. and Adler, J. Isolation of glutamic acid methyl ester from an Escherichia coli membrane protein involved in chemotaxis. J. Biol. Chem. 252 (1977) 3214-3218. [PMID: 16888]

3. Simms, S.A., Stock, A.M. and Stock, J.B. Purification and characterization of the S-adenosylmethionine:glutamyl methyltransferase that modifies membrane chemoreceptor proteins in bacteria. J. Biol. Chem. 262 (1987) 8537-8543. [PMID: 3298235]

4. Springer, W.R. and Koshland, D.E., Jr. Identification of a protein methyltransferase as the cheR gene product in the bacterial sensing system. Proc. Natl. Acad. Sci. USA 74 (1977) 533-537. [PMID: 322131]

[EC created 1989 (EC created 1972, modified 1983, modified 1989, part incorporated 1992)]

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