IUBMB Enzyme Nomenclature


Accepted name: protein-histidine N-methyltransferase

Reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein Nτ-methyl-L-histidine

Other name(s): protein methylase IV; protein (histidine) methyltransferase; actin-specific histidine methyltransferase; S-adenosyl methionine:protein-histidine N-methyltransferase

Systematic name: S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase

Comments: Highly specific for histidine residues, for example, in actin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 108022-17-9


1. Vijayasarathy, C. and Narasinga Rao, B.S. Partial purification and characterisation of S-adenosylmethionine:protein-histidine N-methyltransferase from rabbit skeletal muscle. Biochim. Biophys. Acta 923 (1987) 156-165. [PMID: 3801515]

[EC created 1989]

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