IUBMB Enzyme Nomenclature


Accepted name: tetrahydrocolumbamine 2-O-methyltransferase

Reaction: S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine

Other name(s): tetrahydrocolumbamine methyltransferase

Systematic name: S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase

Comments: Involved in the biosynthesis of the berberine alkaloids.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 93792-09-7


1. Beecher, C.W.W. and Kelleher, W.J. Enzymatic study of the late stages of protoberberine alkaloid biosynthesis. Tetrahedron Lett. 25 (1984) 4595-4598.

[EC created 1989]

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