IUBMB Enzyme Nomenclature


Accepted name: thiol S-methyltransferase

Reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a methyl thioether

Other name(s): S-methyltransferase; thiol methyltransferase; TMT

Systematic name: S-adenosyl-L-methionine:thiol S-methyltransferase

Comments: H2S and a variety of alkyl, aryl and heterocyclic thiols and hydroxy thiols can act as acceptors.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, CAS registry number: 9029-81-6


1. Borchardt, R.T. and Cheng, C.F. Purification and characterization of rat liver microsomal thiol methyltransferase. Biochim. Biophys. Acta 522 (1978) 340-353. [PMID: 623768]

2. Bremer, J. and Greenberg, D.M. Enzymic methylation of foreign sulfhydryl compounds Biochim. Biophys. Acta 46 (1961) 217-224.

3. Weisiger, R.A. and Jakoby, W.B. Thiol S-methyltransferase from rat liver. Arch. Biochem. Biophys. 196 (1979) 631-637. [PMID: 485170]

[EC created 1965]

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