IUBMB Enzyme Nomenclature


Accepted name: GDP-perosamine N-formyltransferase

Reaction: 10-formyltetrahydrofolate + GDP-α-D-perosamine = tetrahydrofolate + GDP-N-formyl-α-D-perosamine

Glossary: GDP-α-D-perosamine = GDP-4-amino-4,6-dideoxy-α-D-mannose

Other name(s): wbkC (gene name)

Systematic name: 10-formyltetrahydrofolate:GDP-α-D-perosamine N-formyltransferase

Comments: The enzyme, characterized from the bacterium Brucella melitensis, synthesizes a building block of the O antigen produced by Brucella species.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Godfroid, F., Cloeckaert, A., Taminiau, B., Danese, I., Tibor, A., de Bolle, X., Mertens, P. and Letesson, J.J. Genetic organisation of the lipopolysaccharide O-antigen biosynthesis region of Brucella melitensis 16M (wbk). Res. Microbiol. 151 (2000) 655-668. [PMID: 11081580]

2. Riegert, A.S., Chantigian, D.P., Thoden, J.B., Tipton, P.A. and Holden, H.M. Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis. Biochemistry 56 (2017) 3657-3668. [PMID: 28636341]

[EC created 2021]

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