IUBMB Enzyme Nomenclature

EC 2.1.3.6

Accepted name: putrescine carbamoyltransferase

Reaction: carbamoyl phosphate + putrescine = phosphate + N-carbamoylputrescine

Other name(s): PTCase; putrescine synthase; putrescine transcarbamylase

Systematic name: carbamoyl-phosphate:putrescine carbamoyltransferase

Comments: The plant enzyme also catalyses the reactions of EC 2.1.3.3 ornithine carbamoyltransferase, EC 2.7.2.2 carbamate kinase and EC 3.5.3.12 agmatine deiminase, thus acting as putrescine synthase, converting agmatine [(4-aminobutyl)guanidine] and ornithine into putrescine and citrulline, respectively.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9076-55-5

References:

1. Roon, R.J. and Barker, H.A. Fermentation of agmatine in Streptococcus faecalis: occurrence of putrescine transcarbamoylase. J. Bacteriol. 109 (1972) 44-50. [PMID: 4621632]

2. Srivenugopal, K.S. and Adiga, P.R. Enzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase). J. Biol. Chem. 256 (1981) 9532-9541. [PMID: 6895223]

[EC 2.1.3.6 created 1976]


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