Reaction: L-arginine + L-lysine = L-ornithine + L-homoarginine
Glossary: phaseolotoxin = N5-[amino(sulfoamino)phosphoryl]-L-ornithyl-L-alanyl-L-arginine
Other name(s): amtA (gene name)
Systematic name: L-arginine:L-lysine amidinotransferase
Comments: The enzyme, characterized from the bacterium Pseudomonas savastanoi pv. phaseolicola, is involved in the biosynthesis of the toxin phaseolotoxin, a modified tripeptide that causes the 'halo blight' disease of beans.
1. Hernandez-Guzman, G. and Alvarez-Morales, A. Isolation and characterization of the gene coding for the amidinotransferase involved in the biosynthesis of phaseolotoxin in Pseudomonas syringae pv. phaseolicola. Mol. Plant Microbe Interact. 14 (2001) 545-554. [PMID: 11310742]
2. Li, M., Chen, L., Deng, Z. and Zhao, C. Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins. FEBS Open Bio 6 (2016) 603-609. [PMID: 27419063]